Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Adherence to all Good Manufacturing Practices (GMP) Safety Standards, Cold Room/Freezers -22degreesF/-6degrees C, Fluctuating Temps hot/cold, Laboratory Setting, Loud Noises (Equipment/Machinery), Office, Rapid flashing lights, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.), Strong Odors (chemical, lubricants, biological products etc.), Will work with hazardous/toxic materials
Job Description
Job Title: ScientistIII, Protein Biology
Job Location: India, Bangalore
About Company:
About the company
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $44 billion. Our Mission is to enable our customers to make the world healthier, cleaner, and safer. Whether our customers are accelerating life sciences research, solving analytical challenges, growing efficiency in their laboratories, improving patient health through diagnostics, or developing and manufacturing life-changing therapies, we are here to support them. Our distributed team delivers an outstanding combination of innovative technologies, purchasing convenience, and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD. Our Innovative Laboratory technologies & Services makes it easier for customers .
About Team: Antibody team
The antibody team is involved in engineering and development of antibodies, with a deep focus on reagent quality and specificity. The core activities of team include design, development, purification, conjugation and testing of antibodies in a variety of immunoassay applications using pioneering tools and technologies. The goal of the program is advanced product development and creation of product specific information to promote research use.
Role & Responsibilities
To play a crucial role within an antibody development team, spearheading the advancement of screening and validation of antibody development through the implementation of cutting-edge molecular, protein, and cell biology techniques.
Responsibilities:
Experimental Design and Execution: Develop and implement experimental strategies for phage display projects, including library construction, selection, and screening. Design and optimize appropriate assays for protein binding or activity measurements.
Selection and Screening: Perform phage display selections to isolate specific binding or functional interactions. Develop and execute appropriate screening protocols, including affinity-based selections or functional assays.
Molecular Biology Techniques: Proficiently perform molecular biology techniques such as PCR, DNA cloning, protein expression, and purification. Ensure quality control measures are implemented to validate constructs and protein production.
Protein Engineering: Utilize phage display to engineer proteins with improved properties, such as increased binding affinity, altered specificity, or enhanced stability. Apply strategies like directed evolution or rational design to optimize protein function.
Data Analysis and Interpretation: Analyze and interpret experimental data. Use statistical methods and bioinformatics tools to identify binding or functional motifs, analyze sequence-activity relationships, and propose protein engineering strategies.
Collaboration and Communication: Collaborate with multidisciplinary teams, including scientists from biology, chemistry, and bioinformatics, to drive project success. Clearly communicate research findings, progress, and recommendations through oral presentations and written reports.
Equipment and Lab Management: Maintain and operate laboratory equipment required. Ensure compliance with safety guidelines, maintain accurate records, and manage inventory and ordering of necessary reagents and supplies.
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