Job Responsibilities :
1. Tissue Sample Processing and Histopathological Analysis:
Be proficient in and participate in the collection and processing of animal tissue samples, including hard-tissue resin embedding, frozen and paraffin-embedded tissue sectioning, immunohistochemistry (IHC), routine histological staining, and in situ hybridization. Independently develop and apply various software tools for histopathological imaging, and biochemical data analysis.
2. Animal Models and In Vivo Studies:
Lead the identification, characterization, and optimization of animal disease models for new research projects.
Participate in experimental design and lead the execution of in vivo animal studies.
Collaborate with CROs and relevant internal functions to ensure effective communication and support the advancement of drug development programs.
3. Cell Biology:
Independently conduct and complete cell-based research activities, including specialized cell screening and characterization, gene transfection and genetic modification, establishment of basic functional cell models, and flow cytometry analysis, to support efficacy evaluation and mechanism-of-action studies. Provide technical guidance and mentorship to junior team members, while actively supporting team capability building
4. Molecular Biology:
Perform routine molecular biology and biochemical assays, including but not limited to genotyping, ELISA, qPCR, Western blotting, and biochemical assays.
Maintain accurate experimental records, document raw data, and perform preliminary data analysis and interpretation.
Independently establish, optimize, and improve analytical methods by leveraging emerging and advanced technologies to support research needs.
5. Experimental Documentation and Compliance Support:
Guide and support junior researchers in maintaining standardized and compliant records of experimental procedures and results.
Organize experimental data and assist in the preparation of study documents, reports, and relevant compliance materials.
Participate in and contribute to the preparation and completion of periodic experimental and project progress reports.
6. Cross-Functional Collaboration and Support:
Provide cross-functional coordination and communication in accordance with project and business needs, as well as other responsibilities assigned by management.
Facilitate effective cross-functional communication and collaboration to ensure alignment on R&D pipeline activities and key timelines, support high-quality execution of R&D projects.
岗位职责：
组织样本处理与病理分析 ：熟知并参与完成动物组织样本的采集与处理，包括硬组织树脂包被、冰冻和石蜡组织切片制备、免疫组织化学染色（IHC）、常规组织染色及原位杂交等实验操作。可独立开发和利用不同软件进行组织病理和生化分析。
动物模型与体内实验 ：负责新项目动物疾病模型发现、鉴定、和优化。参与实验设计并带领体内动物实验操作和执行；协助与CRO及公司内部相关部门沟通，支持药物研发项目推进。
细胞生物学实验 ：独立开展和完成细胞水平研究工作，包括特种细胞筛选鉴定、基因转染和基因改造及基础功能性细胞模型的构建，流式细胞分析等，用于药效评价及机制研究。同时指导团队其他成员，推动团队能力建设。
分子生物学实验操作 ：进行常规分子生物学实验分析，包括但不限于基因型鉴定、ELISA、qPCR、Western Blot、生物化学检测等，按照既定流程完成实验操作、原始数据记录及基础结果整理。瞄准前沿技术独立完成多方面方法学建立和优化提升。
实验记录与合规支持 ：指导和支持初级研究人员规范记录实验过程与结果，整理实验数据，协助完成实验文档、报告及相关合规性材料，并参与和完成阶段性实验结果报告。
多部门协作和支持： 根据项目和业务的要求，及上级安排的其他相关工作，做好相关部门内部协调沟通，确保研发管线进展及项目时间线信息同步，支持项目高效执行。。
Qualifications and Requirements:
1. Educational Background : Master's degree or above in Biology, Biotechnology, Biomedical Sciences, Pharmaceutical Sciences, Basic Medicine, or a related discipline.
2. Work experience: Scientist: Master’s degree with 7–9 years of relevant work experience or Ph.D. (in Physiology, Cell Biology, or a related discipline) with 3-5 years of relevant experience. Postdoctoral research experience (≥2-3 years) is preferred; Sr. Scientist: Master’s degree with 10 years of relevant work experience or Ph.D. (in Physiology, Cell Biology, or a related discipline) with 6 years of relevant experience. Postdoctoral research experience (≥2-3 years) is preferred.
3. Technical Skills and Research Experience
Scientific Background
Strong foundation in biological and biomedical sciences.
Background and research experience in bone, muscle, and joint biology are…