Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. You can learn more about our work here .
Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine.
Our Vision
Pursue large scientific challenges that cannot be pursued in conventional environments
Enable individual investigators to pursue their riskiest and most innovative ideas
Facilitate research by scientists and clinicians at our home institutions and beyond
We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.
The Opportunity
The Advanced Single Cell Technologies group provides critical single cell profiling and perturbation assays, technology, and expertise to the Biohub NY community. The goal of the platform is to develop cutting-edge single-cell technologies in collaborations related to studying human disease and the interaction of immune cells with human organs. More information can be found on the lab website ( https://biohub.org/single-cell-technology-platform/) .
The R&D Engineer II will create new technologies and devices for high throughput single-cell screening and will have demonstrated experience in designing, prototyping, testing and troubleshooting diagnostic or point-of-care medical devices. We are seeking a creative, methodical, resourceful, and technically rigorous engineer capable of driving projects independently and on a team. This role sits at the intersection of device engineering, cell biology/immunology, and reagent formulation, and requires an ability to own a problem end-to-end, from proof-of-concept demonstration to prototype and beyond. This role offers substantial design freedom with direct lab access for rapid testing.
What You'll Do
Design, build and test prototypes for point-of-care sample processing, iterating based on performance data and optimizing for reproducibility
Design mechanisms for controlled timing and sequencing of biochemical processes within a device (e.g., controlled reagent release, passive valving, or equivalent)
Perform hands-on preparation and handling of biological specimens, and conduct assay validation experiments (e.g., timing precision, reagent activity, sample/cell quality at endpoint)
Apply domain knowledge across device engineering, cell biology, and materials science to guide hardware design decisions
Establish test protocols and acceptance criteria to ensure reproducible performance across prototype iterations and production lots
Participate in discussions with project collaborators
Carefully document work
Clearly report on project progress
Contribute to scientific publications and patent applications
What You'll Bring
Bachelor's or Master’s Degree in Engineering (especially biomedical, chemical or mechanical engineering) plus 5+ years of relevant, post-graduate hands-on engineering experience. Holders of non-engineering degrees must have at least 6 years of hands-on engineering experience developing hardware.
Track record of developing diagnostic…