At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.
Position Summary
Bristol Myers Squibb (BMS) seeks an innovative, results-oriented leader to serve as the Iza-Bren Medical Product Lead, Global Medical Oncology. This critical role leads the Global Medical team for Izabren (BMS-986507), a first-in-class EGFRxHER3 bispecific antibody-drug conjugate (ADC) co-developed with SystImmune, with a broad multi-tumor development program spanning breast, lung, gastrointestinal and genitourinary cancers. The MPL will lead a mission-focused team designed to accelerate clinical evidence generation, recruitment, education, and external advocacy across international markets in the rapidly evolving ADC landscape. The MPL will drive a unified strategy, high-velocity execution, and end-to-end ownership across Global Oncology, ensuring best-in-class medical engagement for Izabren as the program advances toward registration and launch. The role will report to the VP, Worldwide Medical Affairs Disease Area Head, Thoracic & H&N Cancers.
Key Responsibilities
Strategy & Direction
In close collaboration with our alliance partner, SystImmune, this role is accountable for:
Develop and execute a unified global medical strategy for Izabren across tumor types and lines of therapy, ensuring speed, clarity, and relentless focus on program goals – in full alignment with the global & US strategy
Lead and manage the dedicated medical Izabren teams at Global and US level, eliminating fragmentation and aligning messaging, evidence, and education across the enterprise.
Drive rapid decision-making and execution, removing delays inherent in traditional matrix models.
Operational Leadership & Accountability
Ensure direct accountability at international, regional, and field levels, enabling real-time progress tracking and immediate intervention.
Optimize trial execution and site engagement across diverse markets for the global Izabren program (including Phase 2/3 and Phase 3 studies in breast cancer, lung cancer and urothelial cancer), in close collaboration with RCO & International Izabren Lead.
Monitor the competitive landscape (including other EGFR-, HER3- and TROP2-directed ADCs, bispecifics and standard-of-care chemotherapy) and proactively adapt strategies to maintain leadership.
Oversee resource allocation, budget management, and strategic prioritization to maximize efficiency and impact.
Establish and monitor KPIs, dashboards, and reporting tools for continuous improvement.
Partner with Clinical Development, Safety, Translational/Biomarker and Regulatory teams to ensure medical insights and real-world evidence needs inform the Izabren development plan and future label.
Collaborate with the Alliance Lead and SystImmune counterparts to ensure joint medical and scientific alignment across territories.
Scientific Advocacy & External Impact
Support building and empower a high-performing, dedicated team of regional Izabren leads and dedicated MSLs, fostering deep scientific advocacy and accelerating site activation, recruitment, and medical education, including ADC-specific topics such as toxicity management, dose optimization and biomarker strategy.
Shape external perception and scientific leadership, leveraging early signal detection and rapid course correction; engage key opinion leaders, investigators and professional societies, and plan data dissemination at key congresses.
Cross-functional collaboration
Partner with the Global Medical, Development, Commercial, Market…