At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.
Job Description
The Senior Scientist will join the Gene Delivery and Editing Process Development (GDEPD) organization supporting process development, production, and characterization of viral vectors, which are critical to generating BMS’s groundbreaking cell therapies. The candidate will help drive next-generation viral vector platform development and support the advancement of clinical programs.
Responsibilities:
Design, execute, and troubleshoot upstream development experiments supporting next-generation LVV and AAV production
Identify, onboard, and develop novel upstream technologies in collaboration with internal and external partners
Optimize production processes and support clinical and commercial scale-up
Ability to design, execute, and lead a platform development strategy, including coordinating the work of junior colleagues and peers
Craft and articulate timelines and resource projections
Leverage knowledge of business needs to communicate progress, risks, and opportunities to senior leaders in the organization
Support cross-functional development efforts e.g. downstream process development, analytical development, pilot plant production, high-throughput process development, etc.
Support research-to-development transitions, including early-stage/pipeline molecular assessment activities
Support late-stage process development activities including process characterization
Actively participate and support lab maintenance, buildout, and continuous improvement initiatives
Work independently and within teams to design, execute, and analyze experiments
Flex between platform development and program development work as necessary
Summarize and present data in group meetings and contribute to group discussions and team strategy
Represent GDPAD within cross-functional teams
Support tech transfer and on-going activities with external collaborators and service providers (CDMOs, CROs)
Model sophisticated knowledge management through authoring of detailed technical reports, study memos, and internal and external presentations/publications
Maintain accurate and detailed laboratory notebook
Basic Qualifications:
Degree in biological or chemical engineering, biochemistry, or bio-related field. PhD with 1+ year relevant industry experience; MS with 5+ years of relevant industry experience; BS with 7+ years relevant industry experience. Title/compensation will ultimately be commensurate with education, experience, and skillset
Subject matter expert with suspension culture of mammalian cells in shake flasks and stirred tank bioreactors
Subject matter expert in process development
Expertise in viral vector process development
Working knowledge of scale up parameters for stirred tank bioreactors
Proven ability to design experiments with DoE approaches, execute DoE designs and interpret the results
Independently motivated with ability to work in cross-functional teams
Experience interfacing with contract manufacturing and development organizations
Ability to communicate clearly and concisely through oral presentations and technical writing
Ability to leverage literature, internal and external resources to solve problems
Desire to identify and advance the cutting edge
Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment
Experience giving presentations at industry conferences
Experience establishing industry (e.g. vendor) and/or academic…