Senior Scientist, Delivery Technologies
CSL's organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we're building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide.
Could you be our next Senior Scientist, Delivery Technologies?
Work Environment:
This position is based in Waltham, MA and is an onsite role 5 days each week. CSL is not providing relocation assistance or visa sponsorship.
You will report to the Principal Scientist, Delivery Technologies
The successful candidate will provide scientific expertise in the design, formulation, characterization, and optimization of delivery technologies to support drug discovery efforts across multiple functions and external collaborations. This role requires strong expertise in lipid nanoparticle (LNP) formulation, extra-hepatic targeted delivery approaches, siRNA-conjugates to enable tissue- and cell-specific delivery, and extensive knowledge in translational drug delivery sciences.
Key Responsibilities
Contribute and support CSL’s novel modalities portfolio and pipeline
Participate in external due diligence, assessing delivery system suitability for various modalities, technical feasibility, and risk
Lead the design, formulation, and characterization of LNPs containing siRNA, mRNA, gene-editing cargoes, and other nucleic acid modalities
Design and execute Design of Experiment (DOE) principles in formulation screening
Work on medium to high throughput formulation preparation
Optimize formulation parameters, lipid composition, manufacturing processes, and excipient systems to enhance stability and biological performance
Develop and characterize targeted delivery strategies (t-LNP) utilizing receptor-mediated uptake mechanisms, targeting ligands, and tissue-specific delivery approaches
Lead efforts related to the design and evaluation of ligand-siRNA conjugates for extrahepatic delivery
Evaluate delivery performance through in vitro and in vivo studies, including cellular uptake, endosomal escape, biodistribution, and target engagement
Serve as a subject matter expert in delivery approaches and LNP process development, and provide technical delivery-related support across research, development, and manufacturing activities
Apply mechanistic insights into critical process parameters and product attributes through hypothesis-driven experimentation, robust data analysis, and problem-solving
Provide scientific guidance and mentorship to team members and collaborate closely with Analytical Biochemistry and Molecular Biology teams
Minimum Qualifications:
PhD with 5+ years or MS with 7+ years of relevant experience in Pharmaceutical Sciences, Nanomedicine, Biomedical Engineering, Chemistry, Chemical Engineering, Drug Delivery, in the pharmaceutical industry
Demonstrated ability to independently lead scientific projects and experience working in cross-functional research environments
Strong track record in LNP formulation and optimization
Expertise in nanoparticle characterization techniques including particle size, encapsulation efficiency, and stability assessment
Expertise in in vitro and in vivo evaluation of RNA-based delivery systems
Understanding of cellular uptake mechanisms, intracellular trafficking, and endosomal escape
Demonstrated experience with targeted LNPs and extrahepatic delivery platforms
Experimental design, statistical analysis, and data interpretation
Preferred: Knowledge of medicinal chemistry principles related to ionizable lipid design, structure-activity relationships (SAR), ligand optimization and linker chemistry
The minimum and maximum base salary range that CSL expects to pay for this position at the Waltham, MA USA work location at the time of this posting is $126,000/yr - $157,000/yr. Individual base salary for a successful candidate is…