Job Title: VP, Head of Cyprotex US ADMET Operations
Location: Princeton, NJ
Reports To: EVP, Head of Global Cyprotex ADME-Tox
About Us: this is who we are
Cyprotex, an Evotec company, specializes in ADME-Tox and Biosciences including both in vitro (laboratory experiments) and in silico (computer modelling) approaches. Cyprotex was founded in 1999. The Company serves the Pharmaceutical and Biotech, Cosmetics/Personal Care and Chemicals Industries as well as academia and not-for-profit organizations. Over 1700 organizations trust Cyprotex for their ADME-Tox and Bioscience research needs.
The Role: Your challenge …in our journey
We are seeking an enthusiastic DMPK scientist to lead our US ADME Sciences function. Responsible for managing the scientists and resources that provide our high-throughput and custom ADME services as well as leadership to our Biotransformation and Bioanalysis functions. Leading the development of new methods and technologies and implementing process improvements, this role is pivotal in maintaining Cyprotex’ reputation in the ADME field.
The individual will work closely with the Director of Scientific Operations and the other Heads of functions to be part of the core operational management structure responsible for day-to-day decision making and improvements across Cyprotex in the US. This role is based in Princeton, New Jersey.
What You’ll Do:
Job Responsibilities
· To lead the US ADME and Safety sciences functions and manage the resources, both personnel and instrumentation, within that group. To drive-forward the techniques used at Cyprotex and to ensure that quality and efficiency are always maintained. To ensure that a wide-range of chemistries can be assessed including compounds and ingredients from chemical and personal care industries as well as typical small molecule pharmaceutical compounds.
· To investigate new instrumentation and assess suitability for integration into Cyprotex systems. To then work closely with the Cyprotex Information Systems Team to integrate new technology and procedures into the Cyprotex LIMS.
· To work closely with the Head of Global Operations, Cyprotex and other Heads of Functions to help oversee the core operational activities of Cyprotex in the US.
· To take a proactive role in developing the ADME and Safety Sciences functions and provide advice to the Cyprotex Leadership Team, where appropriate. To raise the scientific profile of the company by actively pursuing opportunities to present Cyprotex externally.
· To identify areas within the ADME Sciences function for improvement, promote efficiency, and to modify approaches to sample analysis as the customer landscape changes.
· To support the Business Development team with preparing proposals for clients and developing client relationships by occasional site visits and teleconferences. To contribute to plans for new projects including pricing, implementation and sourcing of CapEx.
· To oversee training and development of staff within Cyprotex US Operations and provide scientific direction and line management to staff.
· To directly manage some client studies where the focus of the study is analytical and/or non-standard analytical methods are used.
· To work closely with UK-based colleagues and colleagues within the wider Evotec Group to maintain a consistent approach to ADME and in vitro Safety Sciences.
Who You Are:
Qualifications
PhD trained in ADME sciences from an internationally recognized academic program
Extensive hands-on experience of operating and trouble-shooting ADME and/or in vitro safety assays
Deep experience with LC-MS/MS instrumentation across a range of manufacturers and software applications. Experience with high-resolution mass spectrometry and high-throughput LC techniques desirable.
Exposure to any or both of the following would also be advantageous:
GC-MS including method development.
Analysis of biotherapeutics.
Metabolite…