Company Summary
Prologue Medicines is creating powerful new medicines by unlocking the therapeutic potential of viral proteins. Viral proteins have evolved with humans for millions of years and have been optimized to modulate human biology. Powered by the largest known database of viral protein structures, Prologue’s DELVE™ machine learning platform systematically identifies the proteins that precisely regulate human biology, uncovers new therapeutic targets and programs transformative features into novel therapeutics. Prologue was founded by Flagship Pioneering in 2021.
Position Summary
Prologue Medicines is seeking a highly motivated, focused, and creative Scientist, Cellular Immunology and Inflammation to join our Research and Discovery team. You will advance therapeutic discovery programs by designing, developing and running cellular immunology and inflammation studies that support target validation, biological characterization and mechanism-of-action investigations.
This is a team-based, collaborative role in a matrixed environment. You will work closely with colleagues across disciplines and programs, share ownership of program outcomes, and succeed through partnership as much as individual contribution.
The ideal candidate brings deep expertise in cellular immunology, innate and adaptive immune cell biology, human primary immune cell systems, multiparameter flow cytometry and functional assay development. This is a highly hands-on laboratory role that calls for strong experimental design, analytical thinking and the ability to troubleshoot complex biological assays independently.
In a fast-paced discovery environment, you will generate and interpret high-quality data and contribute to scientific strategy to advance novel therapeutic programs.
Key Responsibilities
Independently design, execute and analyze in vitro and ex vivo cellular immunology and inflammation experiments that support target validation, therapeutic discovery and mechanistic investigations.
Develop, optimize and implement robust cell-based assays to evaluate immune cell activation, differentiation, proliferation, signaling, inflammatory responses and functional outputs.
Apply multiparameter flow cytometry expertise, including panel design, staining optimization, data acquisition, analysis and cell sorting, to characterize immune cell populations and biological responses.
Isolate, culture and manipulate primary human and/or animal immune cells, including innate (e.g., monocytes, macrophages, dendritic cells, neutrophils, NK cells) and adaptive (e.g., T and B cells) populations, using established techniques such as MACS and FACS.
Design and execute phenotypic and mechanism-of-action studies to investigate immune and inflammatory pathways, validate therapeutic targets and test biological hypotheses.
Apply complementary readouts to characterize cellular responses and assess therapeutic activity, including transcriptomic profiling and biomarker and cytokine assays.
Critically analyze experimental data, troubleshoot assay performance and recommend follow-up experiments to inform discovery program decisions.
Collaborate with cross-functional research teams to integrate cellular immunology findings into broader discovery and translational research strategies.
Develop and maintain experimental protocols, assay documentation and laboratory best practices that ensure scientific rigor, reproducibility and data integrity.
Present experimental findings, scientific interpretations and recommendations to cross-functional teams and leadership through presentations, technical discussions and written reports.
Stay current with emerging scientific literature, technologies and methodologies in cellular immunology, inflammation and therapeutic discovery.
Required Qualifications
PhD in Immunology, Cell Biology, Molecular Biology or a related biological discipline, or an M.Sc. with 6+ years of directly relevant experience in cellular immunology (or equivalent combination of…