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Job Description
Role Overview
Gilead Sciences is seeking an exceptional scientific leader to own end-to-end biomarker and translational strategy across a portfolio of inflammatory bowel disease (IBD) and liver programs. This player-coach role requires recognized scientific expertise, demonstrated productivity and the ability to translate human biology and biomarker evidence into high-impact clinical development, regulatory and portfolio decisions.
The Director will establish the GI/liver biomarker roadmap, lead the most complex and strategically important programs and create leverage across assets by integrating tissue, clinical and multi-omic evidence. The role is expected to support several early and late stage programs, with assignments evolving as portfolio priorities change.
This is a site based role at our global headquarters in Foster City, CA.
Key Responsibilities
· Own and continuously evolve the integrated GI/IBD and liver biomarker and translational strategy across multiple clinical-stage assets, aligning evidence generation with disease-area, asset, regulatory and portfolio objectives.
· Lead the most complex programs from early clinical development through Phase II/III, defining decision criteria for target engagement, dose, proof-of-concept, patient selection, response, safety, differentiation and lifecycle opportunities.
· Provide hands-on scientific leadership for analysis and interpretation of blood, stool, intestinal and liver tissue, endoscopic, histologic, imaging, pathology and multi-omic datasets.
· Create cross-asset frameworks for forward and reverse translation, including integrated biopsy strategies and analyses of response, resistance, relapse, patient heterogeneity and mechanisms of action.
· Lead biomarker and translational contributions to protocols, analysis plans, investigator brochures, clinical study reports, briefing documents, regulatory submissions and health authority interactions.
· Partner with senior leaders across Clinical Development, Research, Clinical Pharmacology, Biostatistics, Bioinformatics, Diagnostics, Clinical Operations and Regulatory; clearly articulate scientific opportunities, uncertainties, trade-offs and recommendations.
· Oversee biomarker execution, assay and vendor strategy, budgets, timelines, resources and delivery across several concurrent studies; anticipate risks and establish mitigation plans.
· Establish collaborations with investigators, KOLs, pathologists, consortia and technology partners; represent GI/liver biomarker science at advisory boards, scientific meetings and external forums.
· Lead publication and evidence-dissemination strategy and maintain an active external scientific presence that strengthens the credibility and differentiation of the portfolio.
· Develop direct reports and matrix team…