At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.
Job Description
At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers.
We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come.
As a Scientist, Drug Metabolism at Gilead you will support PK and PK/PD modeling across discovery and development, with an emphasis on large-molecule therapeutics, including biologics, ADCs, and multispecific/T-cell engagers. The role will apply mechanistic and translational modeling to support study design, human PK and dose predictions, and program decision-making.
This is a site-based position at our Foster City campus.
Essential Duties and Job Responsibilities
Provide PK and PK/PD modeling support across discovery and development, with particular emphasis on large molecules, including biologics, ADCs, and multispecific/T-cell engager therapeutics . Contribute to the design and interpretation of nonclinical PK, toxicology, and pharmacology studies.
Contribute to quantitative DMPK strategies by working with interdisciplinary project teams to apply modeling approaches to program questions and decision-making.
Develop and apply mechanistic PK/PD models to address translational questions, support dose selection, and predict first-in-human exposures, including approaches relevant to large-molecule PK, TMDD, target engagement, and nonlinear disposition .
Develop and apply modeling and simulation workflows to support nonclinical study design and data interpretation, incorporating AI-based approaches where appropriate.
Analyze and communicate modeling results and recommendations to project teams, collaborators, and management.
Work with project teams, line management, and CROs to support high-quality and timely delivery of analyses and documents for regulatory submissions.
Contribute quantitative modeling expertise to business development and licensing evaluations.
Requirements:
Ph.D. with 0+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or a related field, with a focus on quantitative PK/PD modeling OR
Masters with 4+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or a related field, with a focus on quantitative PK/PD modeling
Strong foundation in PK/PD principles and mathematical modeling, with knowledge of large-molecule disposition, TMDD, target engagement, and translational PK .
Experience with mechanistic PK/PD and multi-compartmental modeling and proficiency in Phoenix/WinNonlin, MATLAB/SimBiology, R, GastroPlus, or equivalent…