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Job Description
Senior Scientist, Inflammation Biomarkers & Translational Research
Location: Foster City, CA
Department: Biomarkers / Translational Inflammation
Level: Senior Scientist
Role Overview
Gilead Sciences is seeking a highly accomplished Senior Scientist to join the Biomarkers and Translational Inflammation Group in the research organization. This role will provide scientific leadership in the design, development, and execution of biomarker and translational strategies to support clinical programs across inflammatory and fibrotic diseases.
The successful candidate will serve as a biomarker and translational science leader for one or more programs, working closely with Clinical Development, Clinical Pharmacology, Biostatistics, Bioinformatics, Regulatory, and external partners. This position requires deep scientific expertise in human immunology and inflammation, with past success demonstrated through high impact first or senior author publications and/or patents.
Experience in liver/gut biology including fibrotic mechanisms and prior experience in leading biomarker strategy and execution for clinical programs is a strong plus.
Key Responsibilities
Lead the end-to-end biomarker strategy for one or more clinical programs, from early translational research through Phase I-III and registrational studies, aligned with program objectives and regulatory expectations.
Define and implement fit for purpose pharmacodynamic (target engagement, pathway modulation, and pathophysiology changes), MOA, prognostic, predictive, and disease‑monitoring biomarkers, including assay qualification, validation, and transfer to CROs.
Serve as the biomarker lead for cross-functional program teams, providing scientific direction, risk assessment, and contingency planning.
Support inspection-ready biomarker operations, including CRO oversight, vendor management, and data quality assurance.
Design and oversee human-relevant translational studies using primary human samples.
Lead responder vs. nonresponder analyses, pathway interrogation, and reverse‑translation efforts using clinical and real-world data.
Integrate multi-omic, spatial, imaging, and clinical datasets to generate actionable insights and inform program decisions.
Author and review clinical biomarker sections for protocols, IBs, SAPs, and regulatory documents.
Partner with Clinical, Biostats, and Regulatory to ensure biomarker strategies are aligned with registrational and post‑marketing objectives.
Present clinical biomarker data at conferences and investigator meetings, and author biomarker research focused scientific publications.
Contribute to and participate in health authority interactions (e.g., FDA, EMA), including briefing documents, responses, and meetings, representing biomarker and translational strategy.
Engage with external collaborators, consortia,…