At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition from leading workplace and culture organizations, including Science's Top Employers, Great Place To Work® in the U.S., and Fortune's Best Workplaces in BioPharma.
For patients, for each other, and for the future of science, we’re in. Are you?
About the Role:
We’re looking for an Associate Scientist, Drug Formulation on the Research team to help us expand what’s possible for patients with serious diseases. Reporting to the Senior Scientist, Formulation, you’ll focus on the development, optimization, and characterization of nanoparticle (NP)-based drug delivery systems. You will be part of a multidisciplinary team engaged in non-viral vehicle formulation and characterization, supporting platform build and project-level activities.
What You'll Do:
In this role, you’ll have the opportunity to contribute to the advancement of RNA/gene-based therapeutic programs through hands-on formulation science and rigorous analytical evaluation. You’ll also:
Work on formulation and characterization of lipid nanoparticles (LNPs) and other nanoparticle-based delivery systems for platform development and project support
Design and execute formulation studies, including nucleic acid encapsulation into nanoparticle systems, analytical testing, and stability evaluations to finalize formulation compositions for RNA/gene-based therapies
Perform comprehensive physicochemical characterization of nanoparticle formulations, including size, polydispersity index (PDI), surface charge (zeta potential), encapsulation efficiency, drug loading, and release kinetics
Apply a broad set of analytical techniques such as DLS, NTA, UV-Vis spectroscopy, SEC, SDS-PAGE, HPLC, and fluorescence-based assays to evaluate nanoparticles and drug products
Synthesize and develop nanoparticle-based formulations for various therapeutic areas
Support design, synthesis, and purification of protein bioconjugates, including monoclonal antibody and peptide bioconjugation and dye conjugation, as applicable
Characterize and evaluate bioconjugates, including physicochemical properties, stability, conjugation efficiency, and binding ability
Collaborate with team members to troubleshoot formulation challenges and propose data-driven solutions
Perform data and statistical analyses using Excel and GraphPad Prism
Maintain accurate, detailed, and timely records in electronic notebooks and generate internal technical reports
Who You Are:
Basic Qualifications
You meet one of the following minimum education and experience requirements:
Master's degree in Pharmaceutics, Chemistry, Biomedical Engineering, Chemical Engineering, or a related field; OR
Bachelor's degree and 2 years of experience in Pharmaceutics, Chemistry, Biomedical Engineering, Chemical Engineering, or a related field
You are or you also have:
Hands-on experience in nanoparticle-based formulation development and analytical characterization
Preferred Qualifications:
Prior work with nucleic acid delivery systems, especially lipid-based or polymeric nanoparticles
Experience with nucleic acid encapsulation techniques
Experience with bioconjugate and targeted delivery
Proficient in physicochemical and biochemical characterization techniques, including: Dynamic Light Scattering (DLS), Nanoparticle Tracking Analysis (NTA)
Size Exclusion Chromatography (SEC)
UV-Vis Spectroscopy, HPLC, SDS-PAGE
Fluorescence-based assays, protein quantification methods
Strong data analysis and interpretation skills using GraphPad Prism, Excel, or similar tools
Familiarity with stability testing, release profiling, and formulation optimization
Demonstrated ability…