At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.
For patients, for each other, and for the future of science, we’re in. Are you?
About the Role:
We’re looking for a Director, Bioprocess Development on the Biologics Research team to help us expand what’s possible for patients with serious diseases. Reporting to the Senior Director, Biologics Research, you’ll lead the design, buildout, and execution of upstream and downstream capabilities within our Biologics Research organization.
What You'll Do:
In this role, you’ll have the opportunity to Team Leadership & Organizational Build
Build, lead, and mentor a high-performing research bioprocess development team
Establish a collaborative, accountable, and scientifically rigorous team culture
Set priorities and allocate resources across multiple concurrent programs
Laboratory & Capability Development
Design and oversee the buildout of new state-of-the-art research bioprocess development laboratories
Define equipment strategy and select platforms for upstream processing (USP): microbial and mammalian expression systems, as well as downstream processing (DSP): purification workflows including chromatography and filtration
Implement scalable, fit-for-purpose technologies aligned with early-stage and preclinical needs
Technical Leadership (Upstream & Downstream)
Provide subject matter expertise in recombinant protein expression in bacterial and mammalian systems, cell culture process development, media optimization, scale-up strategies, and protein purification processes including flocculation, tangential flow and depth filtration, buffer exchange, and affinity, ion exchange, and mixed mode chromatography
Drive development of robust, reproducible processes suitable for preclinical material generation
Establish platform approaches and best practices for rapid program advancement
Hands-On Execution
Contribute directly to experimental design, experimentation, troubleshooting, and data interpretation
Lead or support critical experiments, especially during early lab setup and high-priority programs
Develop and review protocols, reports, and technical documentation
Program Support & Cross-Functional Collaboration
Partner closely with Discovery, Analytical, Technical Operations, and Preclinical Development teams
Support multiple biologics programs across modalities (e.g., enzymes, antibodies, fusion proteins)
Ensure alignment of bioprocess strategies with program timelines and CMC expectations
Provide input into candidate selection based on developability and manufacturability
CMC & Preclinical Development Interface
Establish processes and documentation to support transition into formal CMC development
Collaborate with external partners or internal CMC teams for tech transfer and scale-up
Ensure early processes are designed with downstream manufacturability in mind
Who You Are:
You have a PhD in chemical engineering, biochemical engineering, biology, or related field with 5+ years of industry experience, or M.S. with 8+ years of industry experience. You are or you also have:
Demonstrated experience in biologics process development within biotech or pharmaceutical settings.
Deep experience in both upstream and downstream bioprocess development.
Expertise in early- to late-stage preclinical CMC for biotherapeutic development candidates.
Hands-on experience with microbial expression systems (specific expertise with E. coli ), mammalian expression systems,…