Title:
Senior Director, Statistical Innovation
Company:
Ipsen Biopharm Ltd
About Ipsen:
Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Supported by nearly 100 years of development experience, with global hubs in the U.S., France and the U.K, we tackle areas of high unmet medical need through research and innovation.
Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries. We build a workplace that champions human-centric leadership and fosters a culture of collaboration, excellence and impact. At Ipsen, every individual is empowered to be their true selves, grow and thrive alongside the company’s success. Join us on our journey towards sustainable growth, creating real impact on patients and society!
For more information, visit us at https://www.ipsen.com/ and follow our latest news on LinkedIn and Instagram .
Job Description:
WHAT - Summary & Purpose of the Position
The Senior Director, Statistical Innovation leads innovative methodology, advanced modelling, and data-driven decision support across Ipsen’s R&D portfolio, strengthening development strategy through design, simulation, and predictive analytics.
The role leads a specialist team of 3 to 5 quantitative experts supporting innovative trial design, advanced modelling, digital twins, virtual controls, patient journey modelling, and data mining to improve development decisions, study efficiency, population selection, and portfolio value.
Working closely with Clinical Development, Biostatistics, Statistical Programming, Translational Medicine, Biomarkers, Regulatory Affairs, Data Science, Business Development, Asset Teams, and Biometry Leadership, the role ensures innovative statistical approaches are scientifically rigorous, operationally feasible, and aligned with regulatory, clinical, and portfolio decision needs.
The role builds a sustainable statistical innovation capability through high-value use cases, standards, reusable tools, external engagement, specialist talent development, and broader Biometry and asset-team upskilling.
WHAT - Main Responsibilities & Technical Competencies
• Lead Statistical Innovation within Biometry, accountable for strategy, priorities, quality, and capability building across a 3 to 5 person specialist team.
• Provide strategic input to innovative trial designs, including adaptive, Bayesian, enrichment, external-control, master protocol, interim, simulation, and endpoint strategies.
• Develop simulation frameworks to assess operating characteristics, optimize sample size, test decision rules, and support go/no-go decisions.
• Lead advanced modelling across clinical development and evidence generation, including disease progression, dose/regimen, patient journeys, digital twins, virtual controls.
• Drive data mining and predictive modelling to identify response predictors, heterogeneity, enrichment opportunities, prognostic factors, and patient subgroups.
• Advise on external controls, digital twins, Bayesian borrowing, historical data, and RWE, addressing bias, confounding, estimands, data quality, regulatory acceptability, and interpretability.
• Identify and implement emerging statistical and modelling approaches for high-impact Ipsen use cases.
• Establish standards, reusable code, templates, documentation, QC expectations, and governance for innovation deliverables.
• Lead and develop statisticians through prioritization, coaching, recruitment input, and succession planning.
• Work with Biostatistics and Statistical Programming to ensure methods are feasible, robust, reproducible, and submission-ready.
• Represent Biometry in governance, asset reviews, development planning, due diligence, and external scientific discussions.
• Build external networks with academics, consortia, and industry groups to maintain methodological…