Site: The Brigham and Women's Hospital, Inc.
Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
The BioTranslation Lab is strongly focused on translational research: we develop materials and delivery technologies that address unmet medical needs and improve patients' lives. Based at Brigham and Women's Hospital and Harvard Medical School, and affiliated with the Broad Institute of MIT and Harvard, we work across chemistry, materials science, biology, engineering, and medicine to advance promising technologies from fundamental design and mechanistic investigation through in vivo validation and toward clinical application.
Our work is driven by a simple principle: rigorous science should ultimately create meaningful new possibilities for patients.
Scientific ownership - Lead an ambitious project and shape its direction from concept through publication.
A translational environment - Connect materials and delivery science with disease biology and clinically relevant questions.
Exceptional collaborations - Join a diverse, international team working across multiple projects and connect with scientific and clinical communities throughout Harvard, MIT, Mass General Brigham, and the Broad Institute.
Career development - Receive support for publications, conference presentations, independent fellowships, and the transition to your next career stage.
Qualifications
POSITION 1 | Chemistry & Materials Science for Long-Acting Therapeutics
Lead project design and execution, including the synthesis and characterization of novel materials and formulation strategies for long-acting injectable and implantable delivery systems. Potential applications include infectious-disease prevention and treatment, substance use disorder, hormonal therapy, and organ transplantation.
Core qualification
Ph.D. or equivalent in chemistry, bioengineering, chemical engineering, materials science, polymer science, pharmaceutical sciences, or a related field.
Experience in one or more of the following would be valuable
Polymer synthesis and characterization
Controlled-release formulations or long-acting drug-delivery systems
Release kinetics, degradation, mechanical or rheological characterization, and relationships to in vivo performance
Scalable and manufacturable formulation or fabrication processes
In vitro and in vivo pharmacokinetic evaluation
POSITION 2 | Non-Viral Delivery of Gene Therapies and Gene-Editing Tools
Lead the engineering and evaluation of lipid nanoparticles, polymeric carriers, and other non-viral systems for RNA therapeutics, gene therapies, and gene-editing tools such as CRISPR/Cas systems. Projects will address delivery efficiency, tissue and cell targeting, and safety in the brain, lung, and other difficult-to-reach tissues.
Core qualification
Ph.D. or equivalent in bioengineering, chemical engineering, molecular biology, pharmaceutical sciences, or a related field.
Experience in one or more of the following would be valuable
Non-viral delivery of nucleic acids, including mRNA, siRNA, or CRISPR/Cas components
Nanoparticle formulation and physicochemical characterization
Targeting, biodistribution, or pharmacokinetic studies
In vitro and in vivo efficacy studies, including expression, knockdown, or editing readouts
Adapting delivery technologies to new tissues and therapeutic targets
POSITION 3 | Immunology and Immunoengineering
Lead mechanistic studies defining the immunological dimensions of BTL's therapeutic platforms, including immunomodulation, neuroinflammation, and host responses to…