The Role
Joining Moderna means advancing mRNA science to transform medicine. Work with exceptional global teams on a broad pipeline and build a career that makes a real difference for patients.
Moderna is strengthening its presence in Norwood, Massachusetts, a cornerstone of our manufacturing and operational excellence. Our Norwood campus translates mRNA science into scalable impact, supporting the global delivery of our medicines. We welcome talent ready to drive innovation and make a meaningful difference for patients worldwide.
In this individual contributor role, you will develop, optimize, and implement advanced analytical methods that support clinical and commercial QC release testing, product characterization, process development, and broader analytical needs across mRNA-based vaccines, therapeutics, and emerging modalities.
You will combine deep hands-on expertise across electrophoretic, microfluidic, automated biomolecule-analysis, immuno-based, and emerging technologies with rigorous experimental design, data interpretation, and phase-appropriate analytical development principles to solve complex product-quality and control-strategy challenges.
Owning defined method-development workstreams from scientific concept through downstream implementation, you will help establish robust, fit-for-purpose and next-generation platform methods that can scale across programs and transition effectively into Moderna’s broader analytical and Quality Control network.
Here’s What You’ll Do
Design, develop, optimize, and execute analytical methods supporting drug substance, drug product, and process intermediates across early development, clinical, and commercial programs.
Develop and evaluate fit-for-purpose electrophoretic, microfluidic, and automated separation-based methods, including capillary electrophoresis, CE-SDS, cIEF/icIEF, microchip electrophoresis, automated gel-based methods, and related technologies where scientifically appropriate.
Develop and optimize automated biomolecule and immuno-based analytical methods, where appropriate, using capillary-based immunoassays, automated Western-type platforms, ligand-binding approaches, and related quantitative biomolecular-analysis technologies.
Evaluate and implement next-generation analytical platforms, including microfluidic and lab-on-a-chip technologies, automated electrophoretic analysis systems, and other emerging technologies that improve robustness, throughput, automation readiness, scalability, or ease of deployment.
Translate product knowledge, critical quality attributes, process-development questions, and control-strategy needs into phase-appropriate analytical requirements and clearly defined method intended use. Select appropriate analytical technologies, sample-preparation strategies, detection approaches, controls, and data-analysis methods based on the scientific question and stage of development.
Apply science- and risk-based analytical development principles, including analytical target profile or intended-use thinking, risk assessment, structured experimentation, Design of Experiments, and ICH Q14/Q2(R2) concepts where appropriate.
Systematically optimize critical method parameters and evaluate analytical performance characteristics including specificity, accuracy, precision, linearity, range, detection capability, robustness, and system suitability to establish scientifically justified operating ranges and controls.
Independently troubleshoot complex analytical challenges and unexpected observations by integrating method-development data, product knowledge, orthogonal analytical results, and scientific literature to develop and test scientifically sound hypotheses and solutions.
Identify opportunities to establish analytical platform methods that can be standardized, harmonized, and reused across related products, programs, laboratories, or modalities, reducing unnecessary method proliferation and accelerating future development.
Evaluate emerging analytical…