City/State:
Bronx, New York Grant Funded:
Yes Department:
Cancer Clinical Trials Office - Operations Work Shift:
Day Work Days:
MON-FRI Scheduled Hours:
9 AM-5 PM Scheduled Daily Hours:
7.5 HOURS Pay Range:
$168,000.00-$210,000.00
The Chief Physician Assistant leads the Phase 1 (early phase) oncology clinical trials program at Montefiore Einstein Comprehensive Cancer Center, an NCI-designated comprehensive cancer center. The role combines program leadership with direct care of pa tients enrolled on first-in-human and early phase trials.
The Chief PA oversees the program's clinical and research operations: advanced practice providers, clinical research staff, the trial portfolio, sponsor and CRO relationships, and quality. The Chief PA works closely with Phase 1 investigators, research nursing, investigational pharmacy, regulatory affairs, and CCTO leadership.
We are looking for an experienced, committed clinician and leader who can grow a high-performing Phase 1 program and expand access to novel therapies for the diverse pa tient population of the Bronx.
Program leadership and administration
Lead daily operations of the Phase 1 program across clinic, infusion, and research functions to ensure safe, efficient enrollment and treatment of trial pa rticipants
Supervise Phase 1 advanced practice providers and research staff (clinical trial managers, research associates), directly or through managers: hiring, onboarding, scheduling, performance evaluations, and professional development
Manage the Phase 1 trial portfolio with the Phase 1 Physician Leader: feasibility review, study selection, prioritization, and capacity planning
Oversee study start-up and activation in pa rtnership with Regulatory Affairs, including site qualification visits and site initiation visits
Manage cohort slot allocation, screening pipelines, and enrollment against sponsor timelines and accrual goals
Serve as the primary operational contact for sponsors and CROs; lead escalation of site performance issues and monitoring findings.
Develop and monitor staffing models, and accrual and productivity metrics; report to CCTO and Cancer Center leadership
Coordinate with investigational pharmacy, research nursing, specimen processing, radiology, and Epic Beacon teams to maintain efficient trial workflows
Lead Phase 1 team meetings and pa rticipate in dose escalation safety reviews and CCTO leadership meetings
APP leadership and clinical oversight
Provide clinical leadership and supervision of Phase 1 advanced practice providers ( PA s and NPs)
Set clinical standards for eligibility assessment, adverse event assessment and grading (CTCAE), dose-limiting toxicity evaluation, and protocol-required documentation
Develop and implement Phase 1 clinical workflows and pa thways, including management of infusion reactions, cytokine release syndrome, and other early phase toxicities
Monitor clinical quality, pa tient safety events, and protocol compliance; lead corrective and preventive actions
Serve as liaison between APPs, investigators, nursing, pharmacy, and administrative leadership
Clinical responsibilities
Under guidance of a supervising MD, maintain a clinical pa nel of pa tients enrolled on early phase trials: review histories, perform physical exams and review of systems, and manage treatment and supportive care
Screen pa tients for trial eligibility in collaboration with investigators and research staff
Explain study pa rticipation to pa tients and families, including treatment options, alternatives, and expected and unexpected side effects; pa rticipate in the informed consent process as delegated by the Principal Investigator
Assess, grade, attribute, and manage adverse events within scope of practice and protocol requirements
Write medical orders for RNs and staff to carry out; ensure protocol-required assessments (labs, PK samples, ECGs, imaging) are ordered and completed in Epic Beacon
Document pa tient care in the EHR in a timely, protocol-compliant manner…