Job Description
Our Company is a global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Our Company has codified its legacy for over a century. Our Company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
At Our Company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthroughs. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility, and scientific acumen of our team. We are creating an organization that is inspired by invention and founded on a culture of respect and collaboration. At Our Company Research Laboratories, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.
The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a strategic-thinking and collaborative Senior Scientist to contribute to Our Company's drug discovery and early clinical development efforts. This position will be based at our research laboratories in West Point, PA.
The ideal candidate will utilize demonstrated expertise in advanced LC/MS techniques to characterize the drug metabolism and pharmacokinetic (DMPK) properties of peptides and protein therapeutics from discovery through early development. Development and implementation of novel bioanalytical and automated workflows, including HRMS and proteomic approaches, to better characterize new modalities will be a key focus area of this role.
The ability to innovate and execute independently while also succeeding in a collaborative team environment is highly desired.
In this exciting position, your primary roles will include:
Independent design and execution of LC-MS methods to characterize therapeutic antibodies, peptides, and various drug conjugates using LC-MS based platforms including high resolution (HRMS) mass spectrometers.
Provide scientific leadership for automation-enabled discovery workflows, helping define future capabilities that increase throughput, reproducibility, and data generation across optimization platforms.
Utilization of state-of-the-art bioanalytical approaches to characterize large molecule drug properties in various in vitro matrices to support candidate selection
Close collaboration with PDMB subject-matter experts in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient strategies to identify and optimize drug candidates
Education Minimum Requirement
Ph.D (with 0 – 3 years relevant experience) or Master’s (minimum of 6 years relevant experience) or Bachelor’s (minimum of 10 years relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field
Required Experience and Skills
Demonstrated method development and validation experience with various platforms with deep expertise in LC/MS for macrocyclic peptides and monoclonal antibodies and drug conjugates
Strong hands-on experience with different chromatographic separation and mass spectrometry methodologies for analysis of therapeutic proteins and peptides.
Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high-quality results in a team-oriented, fast-paced environment
Foster a team-based approach to research. Commitment to working synergistically and harmoniously with others.
Preferred Experience and Skills
Experience with DMPK in vitro and in vivo experimental design and analysis.
Familiarity with electronic laboratory notebooks and related record-keeping…