When joining PerkinElmer, you select an experienced and trusted leader in scientific solutions, with the support of a global service network and distribution centers, providing the right solution, at the right time, to meet critical customer needs. With over an 80+ year legacy of advancing science and a mission of innovating for a healthier world, our dedicated team collaborates closely with commercial, government, academic and healthcare customers to deliver our broad portfolio of analytical solutions, and OneSource services.
Job Title
Conjugation Scientist
Location(s)
Merck (South San Francisco) - Customer Site CA
Job Description
Job Description Summary
We are seeking a highly motivated and exceptional chemist for a position within a Discovery Chemistry Department located at a South San Francisco, CA site. The successful candidate will join multidisciplinary, highly collaborative discovery teams to invent novel medicines by applying optimized conjugation protocols, analytical techniques, and data analysis to synthesize drug candidates and intermediates.
Job Responsibilities:
Perform bioconjugations of linker-payload combinations to antibodies with emphasis on in-house established methods
Select and apply appropriate purification techniques for biologics (i.e., SEC, hydrophobic interaction chromatography, ion exchange chromatography)
Acquire and interpret analytical data such as LC/MS
Document experimental results and present data to project teams
Maintain training and compliance in areas of health and safety, security, environmental and operational aspects of daily activities in the working environment
Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities of this job at any time.
Critical Skills:
Working knowledge of bioconjugation and analytical techniques such as HIC, SEC, RP chromatography, SDS-PAGE, and UV-Vis
Strong foundation in organic chemistry and laboratory synthetic techniques
Excellent interpersonal, collaboration, and communication skills in a team environment
Ability to learn quickly through on-the-job training and become increasingly skilled and independent in reaction setup, route design, and optimization
Basic Qualifications:
B.S. or equivalent degree in chemistry, biochemistry, or related field, with industrial or academic experience with 2+ years of relevant work experience
Preferred Qualifications:
Hands-on experience with conjugation, purification, and characterization of antibody-drug conjugates (ADCs)
Relevant experience applying organic synthesis to the design, preparation, and optimization of small molecules, linker-payloads, or related intermediates
Experience independently designing, executing, and optimizing synthetic routes using modern synthetic techniques
Knowledge of and experience interpreting biological activity data, including structure-activity relationships
Working Environment:
Must be able to work in a laboratory, controlled environments requiring personal protective equipment (e.g., lab coat, safety glasses, etc.) in laboratory.
Job pace may be fast and job completion demands may be high. Must be able to remain in a stationary position more than 25% of the time.
The person needs to occasionally move between labs, corridors, adjoining rooms, and buildings onsite.
Frequently operate on instruments, objects, tools or controls, which will require regularly bending, squatting, stretching and reaching in order to perform in a service function.
Occasionally move or lift up to 25 pounds (potential for occasional lifting of up to 50 pounds).
Specific vision abilities required by this position include without limitation, the ability to observe details at close range distance vision, color vision, peripheral vision, depth perception, and ability to adjust focus in order to perform the essential service functions of this position.
Occasionally operates a computer and other office machinery, such as a calculator, copy machine, and computer…