Job Description
Under the supervision of the Head of NMR, you will join a multidisciplinary Structural Biology and Biophysics team supporting pharmaceutical and biotechnology clients in their drug discovery programs.
Working closely with experts in Surface Plasmon Resonance (SPR), Native Mass Spectrometry, HDX-MS, Cryo-EM and X-ray Crystallography, you will contribute to the characterization of biomolecular interactions and the structural investigation of proteins and protein-ligand complexes.
You will be expected to:
Design, perform and interpret advanced biomolecular NMR experiments for protein and protein-ligand characterization.
Conduct ligand-observed and protein-observed NMR assays to support hit identification, hit validation and fragment-based drug discovery projects.
Perform multidimensional NMR analyses to characterize binding events, chemical shift perturbations and structural changes induced by ligand binding.
Independently perform resonance assignments using state-of-the-art methodologies and computational tools.
Analyze and interpret NMR datasets to provide structural and mechanistic insights supporting client projects.
Contribute to the development, validation and implementation of new NMR methodologies and applications.
Prepare protocols, SOPs and technical documentation.
Present results to internal teams and clients through written and oral reports.
Participate in troubleshooting activities and continuous improvement of NMR workflows and instrumentation.
Profile
We are looking for a dynamic, motivated and scientifically curious NMR scientist to join the Structural Biology and Biophysics team.
Major Requirements
PhD in Structural Biology, NMR Spectroscopy, Biophysics
Strong theoretical and practical expertise in biomolecular NMR spectroscopy.
Hands-on experience operating high-field NMR spectrometers (600, 700 and/or 800 MHz).
Proven experience in the characterization of protein-ligand interactions using ligand-observed and/or protein-observed NMR approaches.
Experience with multidimensional NMR experiments and resonance assignment strategies.
Ability to independently analyze complex datasets and derive biologically relevant conclusions.
Excellent written and verbal communication skills in English.
Strong organizational skills and ability to manage multiple projects simultaneously.
Ability to work efficiently in a multidisciplinary and client-oriented environment.
Additional Assets
Experience in fragment-based drug discovery (FBDD).
Knowledge of complementary biophysical techniques such as SPR, MST, ITC, DLS or Native MS.
Experience in method development and automation of NMR workflows.
Personal Skills
Strong analytical and problem-solving abilities.
Scientific rigor and experimental autonomy.
Ability to translate complex structural information into actionable project recommendations.
Excellent communication and presentation skills.
Collaborative mindset and team spirit.
Curious, innovative and proactive attitude.
Strong client-service orientation.
Languages
Fluent English, written and spoken.
Start of contract: as soon as possible.
Type of contract: permanent position.