When our values align, there's no limit to what we can achieve.
At Parexel, we all share the same goal - to improve the world's health. From clinical trials to regulatory, consulting, and market access, every clinical development solution we provide is underpinned by something special - a deep conviction in what we do.
Each of us, no matter what we do at Parexel, contributes to the development of a therapy that ultimately will benefit a patient. We take our work personally, we do it with empathy and we're committed to making a difference.
About Parexel
Parexel is a leading global clinical development partner delivering insights-driven clinical and consulting solutions to the life sciences industry. With 22,000+ employees worldwide, we partner with biopharmaceutical companies and research sites to design and deliver patient-focused clinical trials that broaden access and make research a care option for anyone, anywhere.
We work with focus, agility, and shared purpose, moving with urgency to address patient needs and accelerate the delivery of new therapies. We embrace bold thinking, adapt quickly to change, and continually raise the bar for the speed and quality of clinical research. We are expanding our team and seeking talented individuals to help drive industry-leading innovation, With Heart®.
About the Role
We are seeking a Senior Clinical Data Manager to join our team in South Africa in a permanent, full-time capacity.
As a Senior Clinical Data Manager, you will play a critical role in supporting global commercial and development programs by leading clinical data management activities across Phase 1-4 studies. This position is central to ensuring the quality, integrity, and reliability of clinical trial data that support the development of innovative therapies for patients worldwide.
You will serve as a key data management leader within cross-functional study teams, driving the planning, execution, and oversight of data management deliverables throughout the clinical trial lifecycle. Responsibilities include leading study-level data management activities, collaborating with internal stakeholders and external vendors, supporting electronic data capture system development and validation, overseeing database lock activities, and ensuring compliance with regulatory requirements and industry standards.
You'll join a fast-paced, growth-oriented environment where your expertise will directly influence study outcomes, operational excellence, and the successful delivery of clinical research programs. With opportunities to work across global studies and collaborate with experienced clinical development professionals, this role offers a meaningful path for continued professional growth and leadership within clinical data management.
Key Responsibilities
Lead large clinical studies or a series of related studies with minimal guidance
Represent Data Management on cross-functional clinical trial working groups for assigned studies
Oversee and monitor data management activities performed by CROs and external vendors while building effective working relationships
Review clinical protocols and provide leadership on data capture strategy, eCRF design, and data collection requirements
Collaborate with CRAs, programmers, study managers, statisticians, and other stakeholders to develop annotated eCRFs and completion guidelines
Lead the development of data edit check specifications, data listings, and study-level data management plans
Coordinate the design, testing, and implementation of Electronic Data Capture systems and resolve system-related issues
Review and provide feedback on study documentation, including monitoring plans, statistical analysis plans, and vendor specifications
Conduct data reconciliations, including Serious Adverse Event reconciliation and external data source reconciliation activities
Lead database upgrades, migrations, user acceptance testing, database freeze activities, and database locks in accordance with company…