Lead at the Intersection of Biology, AI, and Drug Development
At Pfizer, breakthroughs in biology, data science, and artificial intelligence are changing how medicines are discovered and developed.
As the Executive Director, Translational & Computational Biology, you will serve as a senior scientific leader connecting Pfizer's AI Core with therapeutic-area, translational, and clinical teams across Research & Development.
This is not primarily a role for building algorithms or performing downstream analyses. It is a role for identifying high-value biological and clinical questions, translating them into computational and AI-enabled strategies, and ensuring that the resulting evidence informs better scientific, development, and portfolio decisions.
You'll work alongside AI scientists, engineers, computational biologists, translational researchers, clinicians, and therapeutic-area leaders to bring deep biological judgment to some of the most consequential questions in drug discovery and development.
Why This Role Is Different
Lead High-Impact Science Across R&D
This role is designed for an experienced scientific leader ready to take ownership of important biological and translational problems and mobilize the right data, computational approaches, and AI capabilities to address them.
You'll operate with a high degree of autonomy, working across organizational boundaries to frame questions, guide scientific strategy, challenge assumptions, and translate complex evidence into decisions.
Shape How Science Drives Decisions
You'll lead and influence work across areas such as:
· Target identification and validation
· Biomarker discovery and patient stratification
· Mechanisms of response and resistance
· Disease biology and translational research
· Clinical development and trial strategy
· Real-world evidence and lifecycle or post-marketing science
· Business development and external innovation assessments
Most importantly, you'll connect biology, data, and AI to decisions throughout the drug development lifecycle - focusing effort where better evidence can materially change what Pfizer does next.
Move Beyond Downstream Analysis
This is not a downstream analytics role waiting for completed models or narrowly defined requests.
You will help shape the scientific questions themselves, determine what evidence is required, challenge analytical and model assumptions, and translate results into biological and clinical understanding that can influence programs and portfolios.
Operate as a Senior Scientific Partner
You'll partner directly with therapeutic-area, translational, clinical, and AI leaders to identify high-value opportunities, align scientific and analytical strategy, and help teams act on the resulting evidence.
Bridge AI, Data, and Biology to Drive R&D Impact
This role sits at the intersection of the AI Core and Pfizer's scientific and therapeutic-area organizations. You may come from a computational or translational biology background; what matters most is deep biological and scientific judgment combined with the ability to use data, computational approaches, and emerging AI capabilities to answer important questions.
You will identify high-value problems, connect them with the right AI and analytical capabilities, guide study and validation strategy, interpret results in biological and clinical context, and help translate new approaches into scientific practice. You will be an early adopter of AI-enabled ways of working and a trusted partner who helps R&D teams use these capabilities effectively.
The Opportunity
As the Executive Director, Translational & Computational Biology, you will apply deep biological and translational expertise, computational fluency, and scientific judgment to lead AI-enabled work that informs high-value decisions across Research & Development.
Success in this role is measured not by the volume of analyses delivered, but by the quality of the questions selected, the rigor of the evidence generated,…