The Abraham Lab at St. Jude is seeking a Postdoctoral Research Associate to study gene dysregulation, chromatin composition, and genome organization in pediatric cancers.
Position Responsibilities:
This grant-funded position is part of an inter-institutional, interdisciplinary effort to deconvolve the roles of chromatin-modifying enzymes and complexes in cancer-driving gene regulation genome-wide. These proteins represent emerging drug targets in multiple pediatric solid tumors. Interdisciplinary collaboration with chemists and molecular oncologists, specifically the Adam Durbin, Lily Guenther, and Jun Qi (DFCI) labs, will be key components of the work.
The successful candidate will:
Lead computationally focused scientific research projects with increasing independence over time.
Collaborate on project and analysis design under the guidance of multiple invested PIs.
Set personal task-level priorities across multiple interconnected projects.
Develop new computational methods.
Adhere to field and lab standards for data analysis.
Identify, process, organize, interpret, review, and report relevant data.
Direct data collection.
Present research to colleagues within and outside the institution; draft a complex manuscript with minimal supervision, as required.
Perform other duties as assigned to meet the goals and objectives of the department and institution.
Maintains regular and predictable attendance, especially in-person attendance at meetings and relevant presentations.
Minimum Education and/or Training:
Ph.D. degree or equivalent in Bioinformatics, Molecular Biology, Biochemistry, Computer Science, or related field
Special Skills, Knowledge, and Abilities:
Required:
Candidates must hold a doctoral degree (PhD, MD, or equivalent). Applicants with a PhD in a quantitative and biologically oriented field (computational biology, bioinformatics, systems biology, genetics/genomics, statistics, mathematics, computer science, or related fields) are especially encouraged to apply.
Strong candidates from a primarily wet-lab or clinical background who wish to develop sophisticated quantitative skills will also be considered. Such applications would be strengthened by displaying coding experience.
Successful candidates will have a track record of scientific productivity, e.g., a first author paper, or a demonstrable contribution to a large project. Experience in chromatin and expression analysis technologies is desired.
undefined
The initial appointment will be for 1-2 years and can be renewed for up to a total of 5 years, depending on the candidate’s goals and qualifications.
Preferred:
Experience with applied high-throughput sequencing analysis methods, including but not limited to alignment, coverage quantification, differential coverage statistics, and multi-omic integration
About the lab and St. Jude:
Recognized for state-of-the-art computational infrastructure, well-established analytical pipelines, and deep genomic analysis expertise, St. Jude offers a work environment where you will impact the future care of pediatric cancer patients. As a Postdoctoral Research Associate, your responsibilities include analyzing data generated from a variety of second- and third-generation sequencing applications that interrogate gene regulatory biology in health and disease.
The Abraham lab studies gene expression-regulation mechanisms. We are recruiting computational biologists to collaboratively develop software approaches to analyze high-throughput sequencing (-omic) data. We build analytical software pipelines to find answers to biological questions about gene regulation in genome-wide datasets, usually from applied sequencing experiments like CUT&RUN, RNA-Seq (bulk, single-cell, and spatial), and HiChIP, as well as single-cell omic experiments. Our interests center on enhancers and super-enhancers. Specifically, we seek to understand how these regulatory elements establish gene expression programs in healthy cells, and how enhancers are…