Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
Tango’s labs and offices are located at 201 Brookline Avenue, in the vibrant Fenway area of Boston, Massachusetts.
Summary
The Senior Manager, Clinical Data Management serves as the Data Management lead for assigned clinical trials and is responsible for the planning, oversight, execution, and delivery of data management activities from study startup through database lock and study closeout. The role provides sponsor oversight of outsourced data management activities, ensures high-quality and inspection-ready clinical data, and collaborates with cross-functional stakeholders to support trial execution, regulatory compliance, and clinical development objectives.
Your Role:
Serve as the Data Management representative within the Clinical Trial Team (CTT) and provide oversight of Data Management activities throughout the clinical trial lifecycle
Provide sponsor oversight of CRO and external data vendors, ensuring Data Management, IRT and eCOA activities and deliverables are executed in accordance with study requirements, quality standards, timelines, budgets, contractual obligations, and regulatory requirements
Ensure timely delivery of complete, accurate, reliable, and inspection-ready clinical data through effective oversight of outsourced Data Management activities, including EDC, IRT and eCOA system build, validation and maintenance, data collection, data cleaning, medical coding, external data integration and reconciliation, database/system lock, and submission readiness
Review and approve key Data Management deliverables, including CRF/eCRF, IRT, eCOA specifications, edit checks, Data Management Plans, CRF completion guidelines, data transfer specifications, external data reconciliation plans, and other study-specific documentation
Establish and monitor data quality metrics, KPIs, and data review strategies to ensure data integrity, consistency, and compliance throughout the study lifecycle
Lead oversight of external data integrations, transfers, reconciliations, and vendor-managed data streams to ensure completeness, quality, and regulatory compliance
Partner with CTT, CRO and external vendors to support effective planning, integration, review, and reporting of clinical trial data
Identify data-related risks and issues and lead the development, implementation, and monitoring of mitigation and contingency plans
Participate in audits, inspections, and inspection readiness activities and ensure timely assessment, response, and resolution of Data Management-related findings
Contribute to regulatory submissions, health authority responses, and other regulatory deliverables, as required
Support the development and implementation of Data Management standards, processes, technologies, and continuous improvement initiatives
What You Bring:
Bachelor's degree in Computer Science, Life Sciences, Mathematics, Health Sciences, or related field
5+ years of Clinical Data Management experience within the biotechnology, pharmaceutical, or CRO industry
Experience leading Data Management activities for clinical trials in a regulated environment
Experience managing outsourced Data Management activities and providing vendor oversight
Experience managing clinical systems (incl. IRT/ eCOA) configurations and implementations, enhancements, integrations, and technology vendors;
Experience leading User Acceptance Testing (UAT)
Experience supporting database build, data…