- Pay
- $45–67k
- Where
- Smilow Center for Translational
- Level
- Mid
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Posted Job Title
Research Specialist A/B
Job Profile Title
Research Specialist A
Job Description Summary
The Raabe Laboratory at the Perelman School of Medicine, University of Pennsylvania, is seeking a highly motivated Research Specialist A/B to join our research program focused on liver disease, fibrosis, and regenerative medicine.
Job Description
The work includes a variety of cutting-edge molecular and cell biologic techniques to investigate the role of senescence and other fibrosis related pathways in human liver derived organoids and primary human cells in the context of liver disease. Relevant diseases include viral infections and age related fibrotic liver diseases. This work will involve genome editing using CRISPR/Cas9 and siRNA techniques both in organoids /cells and in related mouse models - mostly performed by using lipid nanoparticles. The work involves basic cell culture experimentation (including cell transfection/transduction, stimulation and time course collection), molecular biologic assays (SDS-PAGE, Immunoblotting), and fluorescence microcopy as well as basic data quantification and analysis. The position will also involve assisting with maintaining mouse models, lab organization through ordering of equipment/reagents, maintaining stocks, reagents, chemicals, records, and lab instruments, and attending planning and review meetings. Other duties as assigned.
Research Specialist A: Will work with Dr. Tobias Raabe and team members under general supervision to perform a variety of tasks including; genetic, molecular, and cell biologic techniques to characterize the role of senescence in human liver derived organoids including CRISPR and siRNA - based genome editing. Assist with related mouse experiments. Help with lab organization by ordering reagents and materials, maintaining lab stocks, keeping records, and maintaining lab instruments. Other duties as assigned.
The Research Specialist B position will undertake the duties outlined for the Research Specialist A position, with the additional expectation that the candidate will work independently to develop novel methods and techniques, in addition to undertaking established methods and techniques. This position would also have the added expectation of performing some methods/techniques/data analysis independently, and have a background including more experience, specifically with skills necessary to do data analysis and compilation using appropriate software.
QUALIFICATIONS:
Research Specialist A:
Bachelor of Science and 0 to 1 year of experience or equivalent combination of…