Job Description
General Summary:
The Executive Director, Global Commercial Strategy (GCS) Kidney - Pove will be the senior commercial leader for povetacicept across the kidney indications, including immunoglobulin A nephropathy (IgAN) and primary membranous nephropathy (pMN). The role will own the global commercial strategy for the kidney franchise, supporting the near-term U.S. launch and subsequent global launches in IgAN while advancing pMN toward commercialization.
The Executive Director will co-lead the povetacicept Kidney Program Team with the Development Lead, guiding program strategy and key development, lifecycle, and investment decisions. The role will lead global launch execution and lifecycle management in IgAN and build the global commercialization and launch strategy for pMN.
Key Duties & Responsibilities
Co-lead the povetacicept Kidney Program Team with the Development Lead, setting the integrated strategy, priorities, and decision framework across IgAN and pMN.
Own the global commercial strategy for povetacicept in kidney, connecting launch, lifecycle, development, evidence, and investment priorities across the franchise.
Lead GCS support for the U.S. IgAN launch and subsequent global launches, ensuring clear strategy, critical success factors, regional alignment, readiness, and execution.
Own global lifecycle management for povetacicept in IgAN, identifying and advancing opportunities to strengthen differentiation, expand patient impact, generate evidence, and maximize long-term value.
Lead the global commercialization and launch strategy for pMN, including market development, positioning, target product profile, evidence needs, value proposition, launch sequencing, and readiness.
Shape development plans and lead commercial development activities across IgAN and pMN, including market research, forecasting, competitive intelligence, scenario planning, evidence requirements, and business cases.
Build deep understanding of the IgAN and pMN markets, patients, treatment pathways, competition, access dynamics, and requirements for success.
Ensure alignment between the kidney strategy and broader povetacicept portfolio, partnering with GCS leaders for non-kidney indications while maintaining clear accountability by vertical.
Partner across Development, Medical, Regulatory, Value & Access, Finance, Manufacturing, and regional Commercial teams to deliver a globally aligned strategy and launch plan.
Communicate clear recommendations to senior leaders and governance bodies, identifying key uncertainties, trade-offs, risks, and actions required.
Build and lead a high-performing kidney commercial team as the franchise advances.
Required Education Level
Minimum of a Bachelor’s degree in business, marketing, life sciences, healthcare, or a related field.
Advanced degree such as an MBA, M.S., Pharm.D., Ph.D., or M.D. preferred.
Required Experience
Extensive biopharmaceutical commercial experience, including global commercial strategy, new product planning, or marketing leadership.
Demonstrated experience leading global launch strategy and execution for specialty or rare disease products.
Strong experience in lifecycle management, commercial development, forecasting, evidence strategy, and investment decision-making.
Launch or development experience in nephrology, specialty, rare disease, immunology, or other complex markets; direct kidney experience strongly preferred.
Experience leading cross-functional teams in a matrixed environment; program-team leadership experience preferred.
Exceptional strategic thinking, analytical rigor, business judgment, communication, and influencing skills.
Proven people leadership and ability to build collaborative, high-performing teams.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully…