Job Description
General Summary:
The Senior Project Manager, Commercial Transformation is responsible for leading the planning, coordination, and execution of VITAL ’30 initiative(s) that improve Vertex’s commercial capabilities, operating models and processes. This role will partner with initiative leads, and cross-functional team members from Commercial, DTE, Finance and HR, to design operating model solutions and deliver transformation programs that enable growth and organizational effectiveness.
The successful candidate is a highly organized, collaborative, and outcomes-oriented project leader who can translate strategic priorities into clear plans, manage complex dependencies, identify risks early, and drive accountable execution in a dynamic environment. This is a high-visibility role at the center of Vertex’s commercial transformation agenda, offering direct partnership with senior leadership and the opportunity to shape how the commercial organization operates and grows.
Key Duties and Responsibilities:
Lead end-to-end delivery of commercial transformation initiatives, from VITAL ’30 mobilization through implementation, adoption, and post-launch measurement.
Develop integrated project plans, including objectives, milestones, workstreams, timelines, dependencies, resource needs, and success measures.
Manage vendor relationships, cultivate strong partnerships, and oversee cross-functional teams to ensure work is sequenced effectively and deliverables are completed on time, within scope.
Maintain project governance, meeting cadences, escalation pathways, and presence at decision-making forums.
Monitor progress against plans; proactively identify issues, risks, dependencies, and mitigation actions.
Generate strategic insights; synthesize performance data, benchmarking, stakeholder inputs to surface clear, evidence-based recommendations for senior leadership
Drive organizational change enablement: develop adoption strategies, stakeholder engagement plans, and change impact assessments to support successful transformation
Knowledge and Skills:
Strong knowledge of project management methodologies, including scope, schedule, risk, issue, budget, and stakeholder management.
Strong analytical and proactive problem-solving capabilities; breaks down complex challenges into clear frameworks and actionable recommendations that drive informed decision-making.
Strong written, verbal, facilitation, and executive communication skills.
Adaptability with changing priorities, evolving requirements, and fast-moving business conditions; operates effectively without a fully defined roadmap
Accountability for the deliverables within an initiative, follow-up on actions and facilitation of effective decision-making.
Proficiency in Microsoft Office Suite, particularly PowerPoint for executive communications; familiarity with project management and collaboration tools such as Teams, SharePoint, and Smartsheet
Education and Experience:
Typically requires a bachelor's degree
Typically requires 6 years of experience or the equivalent combination of education and experience
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$139,200 - $208,800
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors…