Location
ST. LOUIS, MO 63108
Scheduled Hours
40
Position Summary
Provides critically complex research and experimentation for department/s allowing the advancement of scientific analysis and discovery. Serves as a subject matter expert offering support, training and guidance relative to the discipline/area. May participate and/or present on the research developed, or the established work of those within the department.
The Pottier Laboratory in the Department of Neurology at Washington University School of Medicine is recruiting a Bioinformatician to join our research on the genetics and transcriptomics of Alzheimer disease, frontotemporal dementia and related neurodegenerative disorders. The position focuses on single-nuclei RNA sequencing (snRNA-seq) of human brain, with additional work in whole-genome sequencing (short- and long-read). You will work closely with the PI, postdocs, other computational scientists and clinical and neuropathology collaborators as part of the NeuroGenomics and Informatics (NGI) Center, a group of more than 20 computational and statistical researchers.
Job Description
Primary Duties & Responsibilities:
Implements: Algorithms and computer software for analyzing omics-based data sets [high-throughput, massively parallel genomic/proteomic/clinical]; Data management and analysis solutions that aid in the storage, investigation and dissemination of large data sets.
Coordinates research project with other investigators and institutions.
Participates in developing hypotheses and experimental design.
Assists with reporting of methods, data and results.
Process and analyze short- and long-read snRNA-seq data, including QC, clustering, cell-type annotation, differential expression and isoform-level analyses.
Process and analyze short- and long-read WGS data, including QC, variant calling, structural variants and association analyses.
Integrate transcriptomic and genetic data with clinical, neuropathological and proteomic data.
Develop, maintain and improve reproducible pipelines on high-performance computing systems as data and tools change.
Organize, back up and share data with collaborators and consortia.
Advise team members and train and supervise junior scientists.
Participate in lab and collaborator meetings.
Contribute to manuscripts, grants and reports, including methods, results and figures.
Working Conditions:
Job Location/Working Conditions
Works in a laboratory environment with potential exposure to biological and chemical hazards
Must be physically able to wear protective equipment and to provide standard care to research animals
Normal office environment.
Physical Effort
Typically sitting at desk or table.
Repetitive wrist, hand or finger movement (PC Typing).
Equipment
Office equipment.
The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.
Required Qualifications
Education:
Bachelor’s degree or combination of education and/or experience may substitute for minimum education.
Certifications /Professional Licenses :
No specific certification/professional license is required for this position.
Work Experience:
Relevant Experience (2 Years)
Skills:
Not Applicable
Driver's License:
A driver's license is not required for this position.
More About This Job
WashU seeks highly motivated individuals who are able to perform duties in a manner consistent with our core mission and guiding principles.
Preferred Qualifications
Education:
Master's degree
Certifications /Professional Licenses :
No additional certification/professional licenses unless stated elsewhere in the job posting.
Work Experience:
No additional work experience unless stated elsewhere in the job posting.
Skills:
Analytical Thinking, Bioinformatics Tools, Communication,…